Home  >  Products  >  Retinoblastoma, Cleaved (Rb, Retinoblastoma 1, Retinoblastoma 1 (Including Osteosarcoma), Rb1, Rb1 Protein, Rb-1, Including Osteosarcoma, OSRC, p105 RB, p105-RB, PP105, PP110, pRb, Retinoblastoma-associated Protein, Retinoblastoma-related Osteosarcoma, Re

Retinoblastoma, Cleaved (Rb, Retinoblastoma 1, Retinoblastoma 1 (Including Osteosarcoma), Rb1, Rb1 Protein, Rb-1, Including Osteosarcoma, OSRC, p105 RB, p105-RB, PP105, PP110, pRb, Retinoblastoma-associated Protein, Retinoblastoma-related Osteosarcoma, Re

Cat no: R1660-09A


Supplier: United States Biological
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The retinoblastoma gene product (Rb) is a tumor suppressor protein and acts as cell cycle regulator (1). Recently, Rb has been shown to play a role in apoptosis. During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. Caspase-3 cleaves Rb into 48 and 68kDa fragments (2-4). Cleavage of Rb would make it functionally inactive, causing release of E2F-1. The E2F-1 then may promote apoptosis (5). Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: camptothecin-treated HL60 (24 hr) Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: R1660-09A
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by immunoaffinity chromatography.
Additional info: Species Crossreactivity: Human, Mouse.

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