Home  >  Products  >  Ras, p21 (c-bas/has, c-H-Ras, c-has/bas p21, C-K-RAS, c-K-Ras2, c-Ki-Ras, c-Kirsten-Ras, c-Ras Ki-2, G1III6 N-Ras, GTPase HRas KRas NRas, H-Ras-1, H-RasIDX, Ha-Ras, HRAS, HRAS1, K-Ras-2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, Kirsten Rat Sarcoma 2 Vi
Ras, p21 (c-bas/has, c-H-Ras, c-has/bas p21, C-K-RAS, c-K-Ras2, c-Ki-Ras, c-Kirsten-Ras, c-Ras Ki-2, G1III6 N-Ras, GTPase HRas KRas NRas, H-Ras-1, H-RasIDX, Ha-Ras, HRAS, HRAS1, K-Ras-2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, Kirsten Rat Sarcoma 2 Vi

Ras, p21 (c-bas/has, c-H-Ras, c-has/bas p21, C-K-RAS, c-K-Ras2, c-Ki-Ras, c-Kirsten-Ras, c-Ras Ki-2, G1III6 N-Ras, GTPase HRas KRas NRas, H-Ras-1, H-RasIDX, Ha-Ras, HRAS, HRAS1, K-Ras-2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, Kirsten Rat Sarcoma 2 Vi

Cat no: R1198-01L

Supplier: United States Biological
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Ras (p21), a signal transducer, was first characterized as the transforming genes of Harvey & Kristen sarcoma virus (1). The Ras family (H-Ras, N-Ras, and K-Ras) regulates cell growth, differentiation and apoptosis (2). Switching from an active or resting state, Ras can either bind GTP or GDP respectively. In the triphosphate conformation, Ras will interact with GTPase activating protein (GAP) to increase its activity (3). Mutations in any of the three isoforms can convert these proteins into active oncogenes. Additionally, Ras mutations are found in 30% of all human cancer (4). Applications: Suitable for use in Flow Cytometry, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:100 Western Blot: 1:1000-1:10,00 Immunoprecipitation: 1:30 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: R1198-01L
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Flow Cytometry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, 40% glycerol.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Ellis RW, et al. Nature. 1981 Aug 6;292(5823):506 2.Campbell, S. L., (1998) Oncogene 17, 1395-1413 3. Zheng, Y., and Quilliam, L. A. (2003) EMBO Rep 4, 463-468 4. Bos JL. Cancer Res. 1989; 49:4682
Additional info: Recognizes human H-Ras, N-Ras and K-Ras. Species Crossreactivity: mouse and rat.

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