Home  >  Products  >  RANK (Receptor Activator of NF-kB, Nuclear Factor kappa B, Receptor Activator of NFkB, Activator of NFkB, CD265, EOF, FEO, mRANK, NFKB Activator, Osteoclast Differentiation Factor Receptor, ODFR, OFE, PDB2, Tumor Necrosis Factor Receptor Superfamily Membe
RANK (Receptor Activator of NF-kB, Nuclear Factor kappa B, Receptor Activator of NFkB, Activator of NFkB, CD265, EOF, FEO, mRANK, NFKB Activator, Osteoclast Differentiation Factor Receptor, ODFR, OFE, PDB2, Tumor Necrosis Factor Receptor Superfamily Membe

RANK (Receptor Activator of NF-kB, Nuclear Factor kappa B, Receptor Activator of NFkB, Activator of NFkB, CD265, EOF, FEO, mRANK, NFKB Activator, Osteoclast Differentiation Factor Receptor, ODFR, OFE, PDB2, Tumor Necrosis Factor Receptor Superfamily Membe

Cat no: R1075-04D

Supplier: United States Biological
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Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2. Applications: Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry: Paraffin-embedded sections Western Blot: 1-2ug/ml Flow Cytometry: Cell surface Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: R1075-04D
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
Alternative names: CD265 Antigen
References: 1. Anderson, D.M, Maraskovsky, E., Billingsley, W.L., Dougall, W.C., Tometsko, M.E., Roux, E.R., Teepe, M.C., DuBose, R.F., Cosman, D., and Gaibert, L. Nature 390: 175-179 (1997). 2. Wong, B.R., Josien, R., Lee, S.W., Sauter, B., Li, H-L., Steinman, R.M., and Choi, Y. J. Exp. Med. 186: 2075-2080. 3. Darnay, B.G., Haridas, V., Ni, J., Moore, P.A., and Aggarwal, B.B. J. Biol. Chem 273: 20551-20555 (1998). 4. Darnay, B.G., Ni, J., Moore, P.A., and Aggarwal, B.B. J. Biol. Chem. 274: 7724-7731 (1999).
Additional info: Recognizes human RANK. In RAW cells, a band at ~97kD. Recognizes an epitope located between aa330-427 of human RANK. Species Crossreactivity: mouse

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