Home  >  Products  >  RAIDD (RIP-associated ICH1/CED3-homologous Protein with Death Domain, RIP-associated Protein with a Death Domain, CASP2 and RIPK1 Domain Containing Adaptor with Death Domain, Caspase and RIP Adaptor with Death Domain, CRADD, Death Adaptor Molecule RAIDD,
RAIDD (RIP-associated ICH1/CED3-homologous Protein with Death Domain, RIP-associated Protein with a Death Domain, CASP2 and RIPK1 Domain Containing Adaptor with Death Domain, Caspase and RIP Adaptor with Death Domain, CRADD, Death Adaptor Molecule RAIDD,

RAIDD (RIP-associated ICH1/CED3-homologous Protein with Death Domain, RIP-associated Protein with a Death Domain, CASP2 and RIPK1 Domain Containing Adaptor with Death Domain, Caspase and RIP Adaptor with Death Domain, CRADD, Death Adaptor Molecule RAIDD,

Cat no: R1032-02H

Supplier: United States Biological
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RAIDD (RIP-associated ICH-1/CED-3-homologous protein with a death domain), is a dual-domain adaptor protein that is constitutively expressed in many tissues (1, 2). RAIDD has an N-terminal caspase recruitment domain (CARD) that interacts with the CARD of caspase-2, and a C-terminal death domain (DD) that interacts with the DD in PIDD (p53-induced protein with a death domain) (3). RAIDD has been shown to mediate the recruitment of CASPASE-2 to tumor necrosis factor receptor-1 (TNF-R1) signalling complex through RIP kinase. Apart from its established role in apoptosis, RAIDD may have an additional function in cell differentiation, supported by its expression in developing organs derived from the ectoderm, like heart and kidney. In developing heart and kidney RAIDD expression patterns are reported to overlap with known zones of cell death suggesting RAIDD may be involved in apoptosis-mediated remodeling (1). Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000
Catalogue number: R1032-02H
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Motaln H, et al. Transgenic Research, 14(1):27-40(14),2005 2. Ahmad M, et al. Cancer Res 57(4):615-9, 1997 3. Park HH, et al. J Mol Biol. 357(2):358-64, 2006
Additional info: Recognizes human RAIDD. Species crossreactvity: rat.

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