Purified anti-NKX2-1 (TTF-1)

Cat no: 655402

Supplier: BioLegend

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Description
Additional Information

NKX2-1 is a homeodomain containing transcription factor, responsible for regulating normal development and maintaining physiological functions of the lung, thyroid, and central nervous system. NKX2-1 appears to play a dual role in lung carcinogenesis. In lung tumors, NKX2-1 expression is significantly amplified. NKX2-1 is required for survival of lung adenocarcinoma and considered as a lineage survival oncogene. However, loss of NKX2-1 promotes metastasis in mouse lung adenocarcinoma. Lower NKX2-1 expression in human lung carcinoma have worse prognoses, suggesting that NKX2-1 inhibits tumor metastasis and acts as a tumor suppressor.

Catalogue number:	655402
Reactivities:	Human
Hosts:	Mouse
Applications:	Western Blot
Size:	100 microg
Clone:	14D3A28
Gene:	7080
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	Upon receipt, store undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Partial NKX2-1 recombinant protein (1-122 aa)
Isotype:	Mouse IgG2a, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	NK-2, TEBP, NKX2A, TITF1, TTF-1, NKX2.1, TTF1 NKX2