Purified anti-c-REL

Cat no: 655802

Supplier: BioLegend

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Description
Additional Information

c-Rel is a member of the Rel/NF-kappaB transcription factor family that forms homo or heterodimers with family members such as RelA/p65, RelB, NF-kappaB1/p105, and NF-kappaB2/p100. The NF-kappaB complex is retained in cytoplasm by the inhibitor IkappaB protein in unstimulated cells. Upon activation, IkappaB is degraded via the ubiquitin-proteasome pathway, which results in nuclear translocation of the active NF-kappaB complex. While other NF-kappaB transcription factors are expressed in most cell types, relatively higher levels of c-REL expression are found in hematopoietic cells. c-REL is thought to play key roles in regulating proliferation, differentiation, and survival of B and T lymphocytes.

Catalogue number:	655802
Reactivities:	Human
Hosts:	Mouse
Applications:	Western Blot
Size:	100 microg
Clone:	2F5A22
Gene:	5966
Dilutions:	Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	Upon receipt, store undiluted at 4C.
Concentration:	0.5 mg/ml
Antigen:	Partial c-REL recombinant protein (453-587 a.a.)
Isotype:	Mouse IgG2b, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	REL, V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog, Proto-Oncogene C-Rel