Protein C is a vitamin K-dependent serine protease that plays a major role in blood coagulation. Binding of Protein C to Endothelial Cell Protein C Receptor (EPCR, also CD201) leads to the proteolytic activation of PAR1 (protease-activated receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes. EPCR is a type I transmembrane
glycoprotein in the CD1/MHC family. It is expressed most strongly in endothelial cells of arteries and veins, and in the heart and lungs. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares ~61% amino acid sequence homology.
Applications:
Suitable for use in Flow Cytometry. Other applications not tested.
Recommended Dilution:
Flow Cytometry: 10ul labels 1-2.5x10e5 cells
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Freezing Allophycocyanin conjugates will result in a substantial loss of enzymatic activity.
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