Home  >  Products  >  Presenilin 2 (PSEN2, PS-2, STM-2, E5-1, AD3LP, AD5, Presenilin-2 NTF Subunit, Presenilin-2 CTF Subunit, AD4, PS2, PSNL2, STM2)
Presenilin 2 (PSEN2, PS-2, STM-2, E5-1, AD3LP, AD5, Presenilin-2 NTF Subunit, Presenilin-2 CTF Subunit, AD4, PS2, PSNL2, STM2)

Presenilin 2 (PSEN2, PS-2, STM-2, E5-1, AD3LP, AD5, Presenilin-2 NTF Subunit, Presenilin-2 CTF Subunit, AD4, PS2, PSNL2, STM2)

Cat no: P6300-47J

Supplier: United States Biological
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Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer's disease, probably functioning through its associated g-secretase activity for amyloid-b protein processing. Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed N-terminus (~34kD) and C-terminus (~20kD) fragments. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2-4ug/ml Immunoprecipitation: 20ug/ml Immunohistochemistry: 20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P6300-47J
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 1% BSA, 0.02% thimerosal, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes human Presenilin 2. Species Crossreactivity: mouse and rat.

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