Home  >  Products  >  Pregnancy Associated Plasma Protein A (PAPP-A, Pappalysin 1, PAPA, PAPPA, PAPP-A, PAPPA1, Aspecific BCL2 ARE-binding Protein 2, ASBABP2, Differentially Placenta 1 Expressed Protein, DIPLA1, EC 3.4.24.79, IGF-dependent IGFBP-4 Protease, IGFBP-4ase, Insulin

Pregnancy Associated Plasma Protein A (PAPP-A, Pappalysin 1, PAPA, PAPPA, PAPP-A, PAPPA1, Aspecific BCL2 ARE-binding Protein 2, ASBABP2, Differentially Placenta 1 Expressed Protein, DIPLA1, EC 3.4.24.79, IGF-dependent IGFBP-4 Protease, IGFBP-4ase, Insulin

Cat no: P6000-80D


Supplier: United States Biological
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Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500kD, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down
Catalogue number: P6000-80D
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by Protein A/G affinity chromatography from culture supernatant.
References: 1. Folkersen J, Grudzinskas JG, Hindersson P, Teisner B, Westergaard JG (1981) Purification of pregnancy-associated plasma protein-A by a two step affinity chromatographic procedure. Placenta 2:11-17. 2. Sinosich MJ, Teisner B, Folkersen J, Saunders DM, Grudzinskas JG (1982) Radioimmunoassay for pregnancy-associated plasma protein A. Clin Chem 28:50-53. 3. Chemnitz J, Folkersen J, Teisner B, Sinosich MJ, Tornehave D, Westergaard JG, Bolton AE, Grudzinskas JG (1986) Comparison of different antibody preparations against pregnancy-associated plasma protein-A (PAPP-A) for use in localization and immunoassay studies. Br J Obstet Gynaecol 93:916-923. 4. Sinosich MJ, Sim RB, Teisner B (1990) Characterization of pregnancy-associated plasma protein-A: comparison with alpha 2-macroglobulin. Biochem Int 20:579-589. 5. Macintosh MC, Iles R, Teisner B, Sharma K, Chard T, Grudzinskas JG, Ward RH, Muller F (1994) Maternal serum human chorionic gonadotrophin and pregnancy-associated plasma protein A, markers for fetal Down syndrome at 8-14 weeks. Prenat Diagn 14:203-208. 6. Casals E, Fortuny A, Grudzinskas JG, Suzuki Y, Teisner B, Comas C, Sanllehy C, Ojuel J, Borrell A, Soler A, Ballesta AM (1996) First-trimester biochemical screening for Down syndrome with the use of PAPP-A, AFP, and beta-hCG. Prenat Diagn 16:405-410.
Additional info: Recognizes native Pregnancy-associated plasma protein A (human, PAPP-A) Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A. The epitope of this product is different from those of clones 6F172 and 6F173. The epitope is located on the PAPP-A subunit of the heterotetramer.

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