Pravastatin sodium is the sodium salt of pravastatin, a ring- opened member of the statin family. Pravastatin is produced biosynthetically from compactin (mevastatin) by a number of micro-organisms, notably Absidia, Cunninghamella, Syncephalastrum, Nocardia or Streptomyces. Typically, statins like compactin, lovastatin and simvastatin possess a b-hydroxy lactone ring which is a pro-drug for the readily ring-opened dihydroxyacid generally regarded as the active HMG-CoA inhibitor. Importantly, the free carboxylic acid enables pravastatin to be freely water soluble within biological pH ranges. Pravastatin is used therapeutically to reduce LDL cholesterol.
Pravastatin from Absidia sp.
Soluble in water, methanol and DMSO.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.