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Cat no: P4262-20

Supplier: United States Biological
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Platensimycin is a novel broad spectrum Gram-positive antibiotic produced by strains of Streptomyces platensis. Its discovery was heralded by high profile publication and commentary in the scientific and lay press. Platensimycin was discovered by target-based whole-cell screening strategy using an antisense differential sensitivity assay based on the inhibition of fatty acid synthesis. Platensimycin inhibits bacterial growth by selectively inhibiting the elongation enzyme, b-ketoacyl acyl carrier protein synthase FabF of the fatty acid synthesis pathway. Source: Platensimycin Molecular Weight: ~441.2 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: P4262-20
Size: 250ug
Form: Supplied as a white to buff solid.
Purity: (same/more than) 95% by HPLC
References: 1. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Wang, J., et al., Nature 441: 358 (2006). 2. Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy. Singh, S.B., et al., J. Am. Chem. Soc. 128: 11,916 (2006).

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