Home  >  Products  >  Phosphatase, Alkaline (PE)

Phosphatase, Alkaline (PE)

Cat no: P4071-22B

Supplier: United States Biological
0 reviews | Write a Review Pencil
Alkaline phosphatase (ALP) is a cell surface enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. Most mammals exhibit four isozymes of ALP with selective expression in distinct tissues; placenta, placenta-like, intestine, and tissue non-specific (1). The liver/bone/kidney isozyme, also called tissue non-specific alkaline phosphatase, was originally cloned from an osteosarcoma cell line screened with anti-liver ALP antiserum (2). Antibodies to ALP have been used in lineage studies to characterize the development of osteoclasts and adipocytes (3, 4). In addition to its expression on the cell surface, neutrophil alkaline phosphatase is found within the secretory granules of neutrophils and is released into the serum (5). Hypophosphatasia, a genetic metabolic disorder resulting from a deficiency in serum and bone alkaline phosphatase activity, manifests itself in patients with severe skeletal defects (6, 7). Neutrophil alkaline phosphatase is often used diagnostically in various pathologies including myeloid cancers (5, 8), Down
Catalogue number: P4071-22B
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Fishman, W.H. (1990) Clin. Biochem. 23:99. 2. Weiss, M.J. et al. (1986) Proc. Natl. Acad. Sci. USA 83:7182. 3. Gronthos, S. et al. (1999) J. Bone Miner. Res. 14:47. 4. Dorheim, M.A. et al. (1993) J. Cell Physiol. 154:317. 5. Tsuruta, T. et al. (1999) Leuk. Lymphoma 32:237. 6. Weiss, M.J. et al. (1988) Proc. Natl. Acad. Sci. USA 85:7666. 7. Iqbal, S.J. et al. (2000) Clin. Chim. Acta 302:49. 8. Dotti, G. (1999) Br. J. Haematol. 105:163. 9. Denier, C.C. et al. (2002) BMC Biochem. 3:2. 10. Tafas, T. et al. (1996) Fetal Diagn. Ther. 11:254. 11. Grozdea, J. et al. (1999) Nature 102:201.
Additional info: Recognizes human Alkaline Phosphatase.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave