PBR (Peripheral-type Benzodiazepine Receptor) is a ubiquitous protein (18kD) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid-producing tissues and is found in association with a 34kD voltage-dependent anion channel protein (VDAC). PBR is involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis.
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Western Blot: 0.5-4ug/ml
Immunohistochemistry (Frozen and paraffin): 10-20ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.