Paxilline is a tremorgenic mycotoxin isolated from species of Penicillium, Acremonium and Emericella. Paxilline acts as a selective blocker of high-conductance Ca2+-activated potassium channels and has been shown to inhibit binding to the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.
Paxilline from Penicillium paxilli.
Soluble in ethanol, methanol, DMF or DMSO. Very poor water solubility.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.