The p21-activated kinase (PAK) family of serine/threonine kinases is engaged in multiple cellular processes, including cytoskeletal recognization, MAPK signaling, apoptotic signaling, control of phagocytes, NADPH oxidase and growth factor-induced neurite outgrowth. Research indicates that phosphorylation of serine 139 of PAK3 which is located in the kinase inhibitory domain, affects the kinase activity.
Suitable for use in Western Blot. Other applications not tested.
Western Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.