Home  >  Products  >  p63 (KET, p51, p40, AIS, p73H, p73L, B(p51A), B(p51B), Chronic Ulcerative Stomatitis Protein, CUSP, EEC3, Keratinocyte Transcription Factor KET, LMS, OFC8, p53-like Transcription Factor, p53 Related Protein, P73, p73H, p73L, RHS, SHFM4, Tumor Protein 63kD

p63 (KET, p51, p40, AIS, p73H, p73L, B(p51A), B(p51B), Chronic Ulcerative Stomatitis Protein, CUSP, EEC3, Keratinocyte Transcription Factor KET, LMS, OFC8, p53-like Transcription Factor, p53 Related Protein, P73, p73H, p73L, RHS, SHFM4, Tumor Protein 63kD

Cat no: P1001-34E1


Supplier: United States Biological
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Recently two genes, termed p63 and p73, have been have been identified and found to encode proteins that share a significant amino-acid identity in the transactivation domain, the DNA binding domain, and the oligomerization domain with p53. Both p63 and p73 can bind to canonical p53-DNA-binding sites, transactivate the promoters of known p53 target genes and induce apoptosis. p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives (DeltaNp63). DeltaNp63 are preferentially expressed in the epithelial basal cells of different organs and have been considered as possible markers of stem cells/reserve cells. Positive Control: A549 or Jurkat Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: P1001-34E1
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ug
Form: PBS containing 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by immunoaffinity chromatography.
Additional info: The p63 antibody was developed against a peptide sequence that is 100% conserved antibody between the alpha, beta, gamma, and delta isoforms of p63 Species Crossreactivity: Human.

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