Home  >  Products  >  p53, phosphorylated (Ser6) (Antigen NY CO 13, Antigen NY-CO-13, Cellular Tumor Antigen p53, Cys 51 Stop, HGNC:11998, LFS1, p53 Cellular Tumor Antigen, p53 Tumor Suppressor, Phosphoprotein p53, Transformation Related Protein 53, TRP53, Tumor Protein p53, T
p53, phosphorylated (Ser6) (Antigen NY CO 13, Antigen NY-CO-13, Cellular Tumor Antigen p53, Cys 51 Stop, HGNC:11998, LFS1, p53 Cellular Tumor Antigen, p53 Tumor Suppressor, Phosphoprotein p53, Transformation Related Protein 53, TRP53, Tumor Protein p53, T

p53, phosphorylated (Ser6) (Antigen NY CO 13, Antigen NY-CO-13, Cellular Tumor Antigen p53, Cys 51 Stop, HGNC:11998, LFS1, p53 Cellular Tumor Antigen, p53 Tumor Suppressor, Phosphoprotein p53, Transformation Related Protein 53, TRP53, Tumor Protein p53, T

Cat no: P1001-27E5

Supplier: United States Biological
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The p53 gene is mutated in approximately half of all human cancers. It is involved in the cellular response to cytotoxic stresses, and together with p19ARF, induces expression of p21Cip1, to cause cell cycle arrest. In addition, p53 is able to induce apoptosis, both by transcriptional and non-transcriptional mechanisms. The amino-terminal 83 amino acids of p53 contain the transactivation domain, as well as the region involved in transcription-independent growth suppression. The carboxy-terminal region contains the DNA-binding domain, which is regulated by three phosphorylation events, and potentially by acetylation also. Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:5000 Immunohistochemistry: 1:250-1:500 Immunocytochemistry: 1:250-1:500 Immunoprecipitation: 1:100 Optimal dilutions to be determined by the researcher. Positive Control: A431 Cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: P1001-27E5
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant.
Additional info: Recognizes human phospho-p53 (Ser6). Does not react with mouse or rat.

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