Home  >  Products  >  p53 (Antigen NY CO 13, Antigen NY-CO-13, Cellular Tumor Antigen p53, Cys 51 Stop, HGNC:11998, LFS1, p53 Cellular Tumor Antigen, p53 Tumor Suppressor, Phosphoprotein p53, Transformation Related Protein 53, TRP53, Tumor Protein p53, TP53, Tumor Suppressor p
p53 (Antigen NY CO 13, Antigen NY-CO-13, Cellular Tumor Antigen p53, Cys 51 Stop, HGNC:11998, LFS1, p53 Cellular Tumor Antigen, p53 Tumor Suppressor, Phosphoprotein p53, Transformation Related Protein 53, TRP53, Tumor Protein p53, TP53, Tumor Suppressor p

p53 (Antigen NY CO 13, Antigen NY-CO-13, Cellular Tumor Antigen p53, Cys 51 Stop, HGNC:11998, LFS1, p53 Cellular Tumor Antigen, p53 Tumor Suppressor, Phosphoprotein p53, Transformation Related Protein 53, TRP53, Tumor Protein p53, TP53, Tumor Suppressor p

Cat no: P1001-29M

Supplier: United States Biological
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p53 is a 50kD tumor suppressor found in increased amounts in a wide variety of transformed cells. It is frequently mutated or inactivated in many types of cancer. P1001-29M is suitable in the research of p53 tumor suppressor gene function and in the detection of p53 expression and/or mutations in clinical specimens. The antibody is applicable as a possible marker in differential diagnosis and prognosis of p53 positive versus p53 negative human tumors. Applications: Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunofluorescence. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:200 Immunohistochemistry: 1:10-1:2000 Immunoprecipitation: 1:50 Western Blot: 1:1000 ELISA: 1:2000 Immunofluorescence (IC): 1:10-1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P1001-29M
Reactivities: Human, Non-Human Primate
Hosts: Mouse
Applications: ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by affinity chromatography.
References: 1. Rossner P <i>et al.</i> Acrylonitrile exposure: the effect on p53 and p21(WAF1) protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts. <i>Mutat Res</i> <b>517</b>:239-50 (2002). 2. Dolezalov&#225; H <i>et al.</i> Epitope analysis of the human p53 tumour suppressor protein. <i>Folia Biol (Praha)</i> <b>43</b>:49-51 (1997). 3. Bartek J <i>et al.</i> Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. <i>Oncogene</i> <b>6</b>:1699-703 (1991). 4. B&#225;rtkov&#225; J <i>et al.</i> p53 protein alterations in human testicular cancer including pre-invasive intratubular germ-cell neoplasia. <i>Int J Cancer</i> <b>49</b>:196-202 (1991).
Additional info: Recognizes aa16-25 of human p53 at ~50kD. Species Crossreactivity: primates

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