Home  >  Products  >  NOXA (Phorbol-12-myristate-13-acetate-induced Protein 1, PMA-induced Protein 1, Immediate-early-response Protein APR, Protein Noxa, PMAIP1)
NOXA (Phorbol-12-myristate-13-acetate-induced Protein 1, PMA-induced Protein 1, Immediate-early-response Protein APR, Protein Noxa, PMAIP1)

NOXA (Phorbol-12-myristate-13-acetate-induced Protein 1, PMA-induced Protein 1, Immediate-early-response Protein APR, Protein Noxa, PMAIP1)

Cat no: N5376-84A

Supplier: United States Biological
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Noxa is a BH3-only member of the Bcl-2 family. Expression of Noxa gene involves direct activation of its promotor by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as Bcl-xL and Mcl-1. Blocking the endogenous Noxa induction results in the suppression of apoptosis. These suggest Noxa may represent a candidate mediator of p53-induced apoptosis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: N5376-84A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
Additional info: Recognizes human Noxa at ~16kD and ~34kD. Species Crossreactivity: mouse and rat.

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