Home  >  Products  >  Neuropilin 1 (Neuropilin-1 Transmembrane Receptor, NP1, NRP, NRP 1, NRP1, NRP-1, BDCA4, CD304, DKFZp686A03134, DKFZp781F1414, NEL-like Protein 1, Nel-related Protein 1, OTTHUMP00000020818, OTTHUMP00000020820, OTTHUMP00000020821, Vascular Endothelial Cell
Neuropilin 1 (Neuropilin-1 Transmembrane Receptor, NP1, NRP, NRP 1, NRP1, NRP-1, BDCA4, CD304, DKFZp686A03134, DKFZp781F1414, NEL-like Protein 1, Nel-related Protein 1, OTTHUMP00000020818, OTTHUMP00000020820, OTTHUMP00000020821, Vascular Endothelial Cell

Neuropilin 1 (Neuropilin-1 Transmembrane Receptor, NP1, NRP, NRP 1, NRP1, NRP-1, BDCA4, CD304, DKFZp686A03134, DKFZp781F1414, NEL-like Protein 1, Nel-related Protein 1, OTTHUMP00000020818, OTTHUMP00000020820, OTTHUMP00000020821, Vascular Endothelial Cell

Cat no: N2176-69

Supplier: United States Biological
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Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neurophilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons.NP-1 isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis and in the formation of certain neuronal circuits and in organogenesis outside the nervous system. The soluble NP-1 isoform 2 binds VEGF(165) and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF(165). NP-1 may bind various members of the semaphorin family. Its expression has an adverse effect on blood vessel number and integrity. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunofluorescence. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:50 Western Blot: 1:1000 Immunoprecipitation: 1:100 Immunohistochemistry (paraffin): 1:100 Optimal dilutions to be determined by the researcher. Positive Control: Human placenta, HUVEC, HepG2 cell lysates, mouse heart tissue, mouse kidney tissue, Rat heart lysate, rat kidney tissue, human kidney tissue Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: N2176-69
Reactivities: Human, Mouse, Rat, Non-Human Primate
Hosts: Rabbit
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Gluzman-Poltorak Z, et al. J Biol Chem 275(24):18040-5, 2000. 2. Shintani Y, et al. EMBO 25(13):3045-55, 2006. 3. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008).
Additional info: Recognizes human Neuropilin 1 at ~130kD. Species Crossreactivity: mouse, rat, monkey

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