Home  >  Products  >  NCoR2 (Nuclear Receptor Co-repressor 2, Nuclear Receptor Corepressor 2, N-CoR2, CTG Repeat Protein 26, CTG26, Silencing Mediator for Retanoid and Thyroid Hormone Receptors, SMAP270, SMRT, SMRTE, SMRTE tau, T3 Receptor-associating Factor, Thyroid Retinoic

NCoR2 (Nuclear Receptor Co-repressor 2, Nuclear Receptor Corepressor 2, N-CoR2, CTG Repeat Protein 26, CTG26, Silencing Mediator for Retanoid and Thyroid Hormone Receptors, SMAP270, SMRT, SMRTE, SMRTE tau, T3 Receptor-associating Factor, Thyroid Retinoic

Cat no: N0555-05D


Supplier: United States Biological
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Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Silencing Mediator of Retinoic acid & Thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR) are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry (Fr). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: N0555-05D
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: PBS, 1 mg/ml BSA, 0.05% sodium azide
P type: Mab
Isotype: IgG1
Purity: Purified
References: Hudelist G et al. Expression of sex steroid receptors and their co-factors in normal and malignant breast tissue: AIB1 is a carcinoma-specific co-activator. Breast Cancer Res Treat 78:193-204 (2003). Thenot S et al. Estrogen receptor cofactors expression in breast and endometrial human cancer cells. Mol Cell Endocrinol 156:85-93 (1999).
Additional info: Species Crossreactivity: Crossreacts with Human.

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