Home  >  Products  >  NALP3 (NACHT-, LRR- and PYD-Containing Protein 3, AGTAVPRL, AII/AVP, Angiotensin/Vasopressin Receptor AII/AVP-like, C1orf7, Cold Autoinflammatory Syndrome 1 Protein, CIAS1, Cryopyrin, Familial Cold Autoinflammatory Syndrome, FCAS, FCU, Muckle-Wells Syndro
NALP3 (NACHT-, LRR- and PYD-Containing Protein 3, AGTAVPRL, AII/AVP, Angiotensin/Vasopressin Receptor AII/AVP-like, C1orf7, Cold Autoinflammatory Syndrome 1 Protein, CIAS1, Cryopyrin, Familial Cold Autoinflammatory Syndrome, FCAS, FCU, Muckle-Wells Syndro

NALP3 (NACHT-, LRR- and PYD-Containing Protein 3, AGTAVPRL, AII/AVP, Angiotensin/Vasopressin Receptor AII/AVP-like, C1orf7, Cold Autoinflammatory Syndrome 1 Protein, CIAS1, Cryopyrin, Familial Cold Autoinflammatory Syndrome, FCAS, FCU, Muckle-Wells Syndro

Cat no: N0018-64G

Supplier: United States Biological
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NALP3 is a cytoplasmic protein belonging to the NLRP family. NALP3 is involved in inflammation and immune response. Research indicates that NALP3 may function as an activator of NF-kappaB signalling and play a role in the regulation of inflammation and apoptosis. Mutations in the NALP3 gene have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). NALP3 is strongly expressed in polymorphonuclear cells, osteoblasts and chondrocytes, NALP3 can also be detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder. Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunocytochemistry: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: N0018-64G
Reactivities: Human
Hosts: Mouse
Applications: Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by affinity chromatography.
References: 1. Martinon F, Tschopp J Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117:561-74 (2004). 2. Chamaillard M et al. Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol 5:581-92 (2003). 3. O'Connor W et al. Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties. J Immunol 171:6329-33 (2003).
Additional info: Recognizes endogenous human NALP3 at ~124kD.

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