Home  >  Products  >  Myb (c-myb, C-myb, c-myb_CDS, AI550390, Avian Myeloblastosis Viral (v-Myb) Oncogene Homolog, efg, M16449, MGC18531, Myb Proto-oncogene Protein, Myeloblastosis Oncogene, v-Myb, v-Myb Avian Myeloblastosis Viral Oncogene Homolog, v-myb myeloblastosis viral o
Myb (c-myb, C-myb, c-myb_CDS, AI550390, Avian Myeloblastosis Viral (v-Myb) Oncogene Homolog, efg, M16449, MGC18531, Myb Proto-oncogene Protein, Myeloblastosis Oncogene, v-Myb, v-Myb Avian Myeloblastosis Viral Oncogene Homolog, v-myb myeloblastosis viral o

Myb (c-myb, C-myb, c-myb_CDS, AI550390, Avian Myeloblastosis Viral (v-Myb) Oncogene Homolog, efg, M16449, MGC18531, Myb Proto-oncogene Protein, Myeloblastosis Oncogene, v-Myb, v-Myb Avian Myeloblastosis Viral Oncogene Homolog, v-myb myeloblastosis viral o

Cat no: M9600-01E

Supplier: United States Biological
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The c-Myb proto-oncogene is a 75kD protein involved in growth regulation and differentiation in many different cell types but it is predominantly expressed in immature hemopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells (2). Disrupting c-myb function might, therefore, prove an effective therapeutic strategy for controlling leukemic cell growth (3). c-Myb binds to promoter sequences of genes such as c-Myc or Bcl-2 that are expressed in cutaneous T-cell lymphoma. Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:10,000 Immunoprecipitation: 1:50 Immunohistochemistry: 1:100-1:250 Immunocytochemistry: 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: M9600-01E
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Kalkbrenner F, et al. Oncogene(5):657-61, 1990 2. Lei W, et al. Blood(10):3855-61, 2005 3. Ratajczak MZ, et al Proc Natl Acad Sci(24):11823-7, 1992
Additional info: Recognizes human c-Myb.

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