Home  >  Products  >  Mre11 (Mre-11, Meiotic Recombination 11, AT-like Disease, Ataxia-telangiectasia Disorder like, ATLD, DNA Recombination and Repair Protein, Double-strand Break Repair Protein MRE11A, Endo/exonuclease Mre11, HNGS1, Meiotic Recombination 11 Homolog A (S. cer

Mre11 (Mre-11, Meiotic Recombination 11, AT-like Disease, Ataxia-telangiectasia Disorder like, ATLD, DNA Recombination and Repair Protein, Double-strand Break Repair Protein MRE11A, Endo/exonuclease Mre11, HNGS1, Meiotic Recombination 11 Homolog A (S. cer

Cat no: M4687-03


Supplier: United States Biological
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Mre11 is an 80kD protein that acts as a Mn+2 dependent double stranded DNA 3'-5' exonuclease and a single stranded DNA endonuclease. It is part of a larger complex with Rad50, p95 (nibrin) and possibly other associated proteins involved in the nuclelytic end-processing of double strand breaks and telomere maintenance. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:100 Immunoprecipitation: 1-5ug/ml Western Blot: 1-5ug/ml Immunohistochemistry (paraffin): 1:100. Requires antigen retrieval; microwave heating in citrate buffer was used. Optimal dilutions to be determined by the researcher. Positive Control: T24 cells Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: M4687-03
Reactivities: Human
Hosts: Mouse
Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
Alternative names: Ataxia telangiectasia Disorder like, Double Strand Break Repair Protein MRE11A, Meiotic Recombination (S. cerevisiae) 11 Homolog A
References: 1. Moreau, S. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining or telomere maintenance. Mol. Cell Bio. 19:556-566, 1999. 2. Carney, J.P. et al. The hMre11/hRad50 protein complex and nimejan breakage syndrome:linkage of double-strand break repair to the cellular DNA damage response. Cell. 93:477-486, 1998. 3. Zhong, Q. et al. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science. 285:747-750, 1999. 4. Trujillo KM <i>et al.</i> Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. <i>J Biol Chem</i> <b>273</b>:21447-50 (1998). <PUBMED:9705271>
Additional info: Recognizes human Mre11.

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