Moniliformin is a potent, water-soluble mycotoxin produced by several species of Fusarium. Comparative studies of the toxicity of moniliformin to chicken cell lines revealed no toxicity to chondrocytes and macrophages, but toxicity to splenocytes, cardiac and skeletal myocytes. Moniliformin selectively inhibits mitochondrial oxidization of pyruvate and a-ketoglutarate, however the mode of action is not yet completely resolved.
Source:
Moniliformin from Fusarium moniliforme.
Molecular Weight:
~120
Solubility:
Soluble in water, methanol and DMSO
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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