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Matrix Metalloproteinases, Colorimetric, BioAssay(TM) Kit

Cat no: M2420-08B

Supplier: United States Biological
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Kit Size 100 Assays (96-well plate) This kit is optimized to detect MMP activity and screen for MMP inhibitors. It provides enough reagents to perform 100 assays in a 96-well format. High Speed: The entire process can be completed in minimal time Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components and processing bioactive mediators.1,2 Based on their role in normal and pathological processes, including embryogenesis, wound healing, inflammation, arthritis,3 and cancer,4,5 MMPs have been chosen as therapeutic targets for the treatment of many diseases. The MMP Assay Kit can be used for the continuous spectrophotometric assay of MMPs activity, including MMP-1, 2, 3, 7, 8, 9, 12, 13, and 14 and for high throughput screening of MMP inducers and inhibitors. The chromogenic substrate is a thiopeptolide that is cleaved by the MMPs, releasing a sulfhydryl group. The sulfhydryl group reacts with Ellman
Catalogue number: M2420-08B
Applications: ELISA
Size: 1Kit
References: 1. Woessner, J.F. Jr. and CJ. Taplin, J. Biol. Chem. 263, 16918 (1988). 2. Woessner, JF. Jr. FASEB J. 5, 2145 (1991). 3. Gravallese, EM. et al. Arthritis Rheum. 34, 1076 (1991). 4. Stetler-Stevenson, WG. et al. Annu. Rev. Cell Biol. 9, 541 (1993). 5. Goldberg, GI. et al. Ann. NY. Acad. Sci. 580, 375 (1990).

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