Home  >  Products  >  MAP Kinase, p44/42, phosphorylated (Thr202,Tyr204) Growth Proliferation Marker IHC Detection Kit, BioAssay(TM)
MAP Kinase, p44/42, phosphorylated (Thr202,Tyr204) Growth Proliferation Marker IHC Detection Kit, BioAssay(TM)

MAP Kinase, p44/42, phosphorylated (Thr202,Tyr204) Growth Proliferation Marker IHC Detection Kit, BioAssay(TM)

Cat no: M2352-31

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Both p44 and p42 MAP kinases (Erk1 and Erk2) function in a protein kinase cascade that plays a critical role in the regulation of cell growth and differentiation (1-4). MAP kinases are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine (202 and 204 of human MAP kinase [Erk1] or 183 and 185 of rat Erk2) at the sequence T*EY* by a single upstream MAP kinase kinase (MEK) (5,6). Both kinases are known to weakly autophosphorylate on tyrosine (5). Specificity/Sensitivity: Growth/Proliferation Marker: Phospho-p44/42 MAPK (Thr202/Tyr204) IHC Detection Kit recognizes endogenous levels of p42 and p44 MAP kinase (Erk1 and Erk2) only when phosphorylated at threonine 202 and tyrosine 204 of human Erk, or threonine 183 and tyrosine 185 of rat Erk2. The antibody does not cross-react with the corresponding phosphorylated residues of either SAPK/JNK or p38. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. For maximum recovery of product, centrifuge the original vials prior to removing the cap.
Catalogue number: M2352-31
Applications: Immunohistochemistry
Size: 1Kit
Purity: Purified by protein A and peptide affinity chromatography.
Additional info: Growth/Proliferation Marker: Phospho-p44/42 MAPK (Thr202/Tyr204) IHC Detection Kit recognizes endogenous levels of p42 and p44 MAP kinase (Erk1 and Erk2) only when phosphorylated at threonine 202 and tyrosine 204 of human Erk, or threonine 183 and tyrosine 185 of rat Erk2. The antibody does not crossreact with the corresponding phosphorylated residues of either SAPK/JNK or p38.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave