Home  >  Products  >  MAP Kinase Kinase 3, NT (Dual Specificity Mitogen-activated Protein Kinase Kinase 3, Mitogen-activated Protein Kinase Kinase 3, MAP2K3, MAPKK 3, MKK3, MAPK/ERK Kinase 3, MEK 3, MEK3, PRKMK3, Stress-activated Protein Kinase Kinase 2, SAPK Kinase 2, SAPKK2,
MAP Kinase Kinase 3, NT (Dual Specificity Mitogen-activated Protein Kinase Kinase 3, Mitogen-activated Protein Kinase Kinase 3, MAP2K3, MAPKK 3, MKK3, MAPK/ERK Kinase 3, MEK 3, MEK3, PRKMK3, Stress-activated Protein Kinase Kinase 2, SAPK Kinase 2, SAPKK2,

MAP Kinase Kinase 3, NT (Dual Specificity Mitogen-activated Protein Kinase Kinase 3, Mitogen-activated Protein Kinase Kinase 3, MAP2K3, MAPKK 3, MKK3, MAPK/ERK Kinase 3, MEK 3, MEK3, PRKMK3, Stress-activated Protein Kinase Kinase 2, SAPK Kinase 2, SAPKK2,

Cat no: M2363-10F

Supplier: United States Biological
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Mitogen-acitvated protein kinase kinase 3 (MKK3) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). MKK3, closely related to MKK6, efficiently phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines and environmental stress but not JNK or ERK (3). MKK3 is activated by mitogenic and environ-mental stress stimulus as well as by insulin. MKK3 is necessary for the expression of glucose transporter and participates in the MAP kinase- mediated signaling cascade (4). Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:20 Western Blot: 1:5,000-20,000 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Freeze at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: M2363-10F
Reactivities: Human
Hosts: Rabbit
Applications: Flow Cytometry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1.Han, J.; et al., J. Biol. Chem. 271: 2886-2891, 1996. 2.Seger, R.; Krebs, E. G. : FASEB J. 9: 726-735, 1995. 3.Bernd Stein, Helen Brady, Maria X. Yang , David B. Young, Miguel S. Barbosa, Volume 271, Number 19, Issue of May 10, 1996 pp. 11427-11433 4.Fujishiro et al. J. Biol. Chem., Vol. 276, Issue 23, 19800-19806, 2001
Additional info: Recognizes human MKK3

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