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Lysosome Associated Membrane Protein 1 (LAMP 1, CD107a, Igp120, IgpA) (PE/CY5)

Lysosome Associated Membrane Protein 1 (LAMP 1, CD107a, Igp120, IgpA) (PE/CY5)

Cat no: L9190-09E

Supplier: United States Biological
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CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.1-7 Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 10ul/10e6 cells. Immunohistochemistry: Acetone-fixed, frozen tissue sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Catalogue number: L9190-09E
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Labeled with PE/CY5.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD107a, 107b Section, Academic Press, New York, p. 389. 3. Sawada, R., K.A. Jardine, and M. Fukuda. 1993. J. Biol. Chem. 268:9014. 4. Febbraio, M., and R.L. Silverstein. 1990. J. Biol. Chem. 265:18531. 5. Chen, J.W., Y. Cha, K.U. Yuksel, R.W. Gracy, and J.T. August. 1988. J. Biol. Chem. 263:8754. 6. Sawada, R., J.B. Lowe, and M. Fukuda. 1993. J. Biol. Chem. 268:12675. 7. Sawada, R., S. Tsuboi, and M. Fukuda. 1994. J. Biol. Chem. 269:1425.
Additional info: Recognizes human CD107a/LAMP 1.

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