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Lysosome Associated Membrane Protein 1 (LAMP 1, CD107a, Igp120, IgpA) (FITC)

Lysosome Associated Membrane Protein 1 (LAMP 1, CD107a, Igp120, IgpA) (FITC)

Cat no: L9190-09A

Supplier: United States Biological
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Lysosomal-associated membrane protein 1 (LAMP-1), also known as CD107a, is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium (1-7). Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 10ul labels10e6 cells Immunohistochemistry: Acetone-fixed frozen tissue sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: L9190-09A
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with FITC.
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD107a, 107b Section, Academic Press, New York, p. 389. 3. Sawada, R., et al., J. Biol. Chem. 268: 9014 (1993). 4. Febbraio, M., & Silverstein, R.L., J. Biol. Chem. 265: 18,531 (1990). 5. Chen, J.W., et al., J. Biol. Chem. 263: 8754 (1988). 6. Sawada, R., et al., J. Biol. Chem. 268: 12,675 (1993). 7. Sawada, R., et al., J. Biol. Chem. 269: 1425 (1994).
Additional info: Recognizes human LAMP 1.

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