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LRP5, LRP6 (Low-density Lipoprotein Receptor-related Protein 5, LRP-5, LR3, LRP7/Low-density Lipoprotein Receptor-related Protein 6, LRP-6)

LRP5, LRP6 (Low-density Lipoprotein Receptor-related Protein 5, LRP-5, LR3, LRP7/Low-density Lipoprotein Receptor-related Protein 6, LRP-6)

Cat no: L2601-05Y1

Supplier: United States Biological
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LDL-related proteins, LRP-5 and LRP-6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP-5 to Axin, leading Axin degradation and beta-Catenin stabilization. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: L2601-05Y1
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in 10mM Tris-glycine, pH 7.0, 0.15M sodium chloride, 0.5% BSA, 0.01% sodium azide, 25% glycerol.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by affinity chromatography.
References: Li, L., et al. (2002) J. Biol. Chem. 277:5977-5981.
Additional info: Recognizes full length and a proteolytic fragment of human LRP-6. Species Crossreactivity: mouse.

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