LMNA (Prelamin-A/C, LMN1)

Cat no: L1220-08J

Supplier: United States Biological

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Description
Additional Information

Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication and chromatin organization. Lamin A is specifically cleaved by caspase-6 and therefore serves as a marker for caspase-6 activation. During apoptosis the 70kD lamin A is cleaved to a large (40-45kD) and small (23kD) fragment. The cleavage of lamins results in nuclear disregulation and cell death. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Immunohistochemistry: 15-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	L1220-08J
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug
Form:	Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type:	Pab
Isotype:	IgG
Purity:	Purified by affinity chromatography.
Additional info:	Recognizes human Lamin A at ~23kD, ~45kD and ~70kD. Species Crossreactivity: mouse and rat.

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LMNA (Prelamin-A/C, LMN1)

Cat no: L1220-08J

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