Home  >  Products  >  LCK, Phosphorylated (Tyr505) (Tyrosine-protein Kinase Lck, Proto-oncogene LCK, Lymphocyte Cell-specific Protein-tyrosine Kinase, p56-LCK, LSK, T Cell-specific Protein-tyrosine Kinase)
LCK, Phosphorylated (Tyr505) (Tyrosine-protein Kinase Lck, Proto-oncogene LCK, Lymphocyte Cell-specific Protein-tyrosine Kinase, p56-LCK, LSK, T Cell-specific Protein-tyrosine Kinase)

LCK, Phosphorylated (Tyr505) (Tyrosine-protein Kinase Lck, Proto-oncogene LCK, Lymphocyte Cell-specific Protein-tyrosine Kinase, p56-LCK, LSK, T Cell-specific Protein-tyrosine Kinase)

Cat no: L1565-15D

Supplier: United States Biological
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Lck is a membrane associated tyrosine protein kinases. The Lck gene has been shown to undergo rearrangement and overexpression in some murine lymphomas. In human studies, it has been demonstrated that the Lck gene is localized to a site in the genome which undergoes frequent chromosomal abnormalities in lymphomas and neuroblastomas. Resting T cells contain high levels of the Lck protein and mRNA both of which decline upon activation of the T cells. These and other observations suggest that alterations in Lck expression may contribute to the pathogenesis of some types of neoplastic disease. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Immunoprecipitation: 10-20ug/ml Immunohistochemistry: 20-25ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: L1565-15D
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 1% BSA, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes human Lck at ~56kD. Species Crossreactivity: mouse and rat.

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