Home  >  Products  >  Lck, phosphorylated (Tyr505) (Lck p56, Lymphocyte Cell Specific Protein Tyrosine Kinase, LSK, Membrane Associated Protein Tyrosine Kinase, Oncogene lck, P56 LCK, p56(LSTRA) Protein Tyrosine Kinase, pp58 lck, Proto-oncogene Tyrosine Protein Kinase LCK, T c
Lck, phosphorylated (Tyr505) (Lck p56, Lymphocyte Cell Specific Protein Tyrosine Kinase, LSK, Membrane Associated Protein Tyrosine Kinase, Oncogene lck, P56 LCK, p56(LSTRA) Protein Tyrosine Kinase, pp58 lck, Proto-oncogene Tyrosine Protein Kinase LCK, T c

Lck, phosphorylated (Tyr505) (Lck p56, Lymphocyte Cell Specific Protein Tyrosine Kinase, LSK, Membrane Associated Protein Tyrosine Kinase, Oncogene lck, P56 LCK, p56(LSTRA) Protein Tyrosine Kinase, pp58 lck, Proto-oncogene Tyrosine Protein Kinase LCK, T c

Cat no: L1565-01M

Supplier: United States Biological
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The human T-cell or lymphocyte specific gene Lck/p56 is a member of the Src family of non-receptors tyrosine kinase. Mostly expressed in T cells, Lck has been shown to be critical for the normal development of T lymphocytes (1). Additionally, the N-terminal region of the tyrosine kinase Lck interacts with the cytoplasmic domains of CD4 and CD8 (2). Autophosphorylation at Tyr-394 appears to be required for maximum catalytic activity (3) but it can also be suppressed by phosphorylation of the carboxyl-terminal tyrosine Tyr-505 (4). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:10,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: L1565-01M
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% Glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Rudd, CE, et al., Proc. Natl. Acad. Sci., U. S. A. 85, 5190 2. Veillette, AM, et al., Cell 55: 301, 1988. 3. Boulet, I., Fagard, R., and Fischer, S. Bichem. Biophys. Res. Commun. 149, 56 4. Nakamura, K., et al., (1993) Oncogene 8, 3133-3139
Additional info: Recognizes human LCK phosphorylated at Tyrosine 505. Species Crossreactivity: Mouse.

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