Home  >  Products  >  Lck (Lck p56, Lymphocyte Cell Specific Protein Tyrosine Kinase, LSK, Membrane Associated Protein Tyrosine Kinase, Oncogene lck, P56 LCK, p56(LSTRA) Protein Tyrosine Kinase, pp58 lck, Proto-oncogene Tyrosine Protein Kinase LCK, T cell Specific Protein Tyro
Lck (Lck p56, Lymphocyte Cell Specific Protein Tyrosine Kinase, LSK, Membrane Associated Protein Tyrosine Kinase, Oncogene lck, P56 LCK, p56(LSTRA) Protein Tyrosine Kinase, pp58 lck, Proto-oncogene Tyrosine Protein Kinase LCK, T cell Specific Protein Tyro

Lck (Lck p56, Lymphocyte Cell Specific Protein Tyrosine Kinase, LSK, Membrane Associated Protein Tyrosine Kinase, Oncogene lck, P56 LCK, p56(LSTRA) Protein Tyrosine Kinase, pp58 lck, Proto-oncogene Tyrosine Protein Kinase LCK, T cell Specific Protein Tyro

Cat no: L1565-01F

Supplier: United States Biological
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Lck (p56lck), a member of the Src family of non-receptor tyrosine protein kinases, is expressed predominantly in T cells. Lck function is critical both for T cell development in the thymus and activation of mature T cells in the periphery by antigen. The activity of Lck is known to be regulated by phosphorylation of two conserved tyrosine residues, Tyr-505 (equivalent to Tyr-529 in c-Src) and Tyr-394 (equivalent to Tyr-418 in c-Src). Cellular Localization: Cytoplasmic Positive Control: Jurkat cell lysate. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: L1565-01F
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: 15mM Sodium Azide in PBS. pH 7.4
P type: Mab
Isotype: IgG1
Purity: Purified by immunoaffinity chromatography.
References: 1. Romagnoli P et al. A potential role for protein tyrosine kinase p56(lck) in rheumatoid arthritis synovial fluid T lymphocyte hyporesponsiveness. Int Immunol 13:305-12 (2001). 2. Cebecauer M et al. Incorporation of leucocyte GPI-anchored proteins and protein tyrosine kinases into lipid-rich membrane domains of COS-7 cells. Biochem Biophys Res Commun 243:706-10 (1998).
Additional info: Recognizes defined epitope (aa 22-36) on p56Ick (Src gene family tyrosine-specific phospho-transferase). Species Crossreactivity: Crossreacts with Human. Does not react with Mouse.

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