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LAG-3 (Lymphocyte Activation Gene-3, FDC Protein, CD223) (PE)

Cat no: L1050-61H

Supplier: United States Biological
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Murine lymphocyte activation gene-3 (LAG-3) is a 70kD activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Applications: Suitable for use in Flow Cytometry and Functional Assays. Other applications have not been tested. Recommended Dilution: Flow Cytometry: Neat to 1:5. Use 10ul to label 10e6 cells in 100ul. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4 degrees C. PE conjugates are sensitive to light.
Catalogue number: L1050-61H
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a powder lyophilized from a solution containing PBS with 1% BSA and 0.09% sodium azide. Reconstitute with 1ml sterile ddH2O. Conjugated to R-Phycoerythrin (PE).
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes murine lymphocyte activation gene-3 (LAG-3). Recognizes an epitope within the D2 domain of CD223. Reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II.

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