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LAG-3 (Lymphocyte Activation Gene-3, FDC Protein, CD223) (ATTO 590)

Cat no: L1050-61B

Supplier: United States Biological
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LAG3 (LAG3, LAG-3, lymphocyte-activation gene 3, CD223, lymphocyte-activation protein 3) Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. Application(s): Immunocytochemistry Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: L1050-61B
Reactivities: Human
Hosts: Mouse
Applications: Immunocytochemistry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified from concentrated hybridoma tissue culture supernatant by Protein A Sepharose CL-4B Flow Fast Column. Highly purified (SDS-PAGE).
References: 1. E. Baixeras, et al. (1992) J. Exp. Med. 176:327. 2. B. Huard, et al. (1994) Immunogenetics 39:213. 3. B. Huard, et al. (1997) PNAS 94:5744. 4. S. Hannier, et al. (1998) J. Immunol. 161:4058. 5. C.E. Demeure, et al. (2001) Eur. J. Cancer 37:1709. 6. F. Triebel, et al. (2005) Cancer Lett. Epub ahead of print. 7. E.D. Carlo, et al. (2005) J. Pathol. 205:82. 8. L. Macon-Lemaitre and F. Triebel (2005) Immunology 115:170.
Additional info: Recognizes the 30 aa extra-loop of the first N-terminal D1 domain of human LAG-3.

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