Home  >  Products  >  Kv4.2 (Kcnd2, KCD2, KIAA1044, MGC119702, MGC119703, Potassium Voltage-gated Channel Shal Related Subfamily Member 2, Potassium Voltage-gated Channel Subfamily D Member 2, RK5, Shal1, Voltage-gated Potassium Channel Subunit Kv4.2, Voltage-sensitive Potassi

Kv4.2 (Kcnd2, KCD2, KIAA1044, MGC119702, MGC119703, Potassium Voltage-gated Channel Shal Related Subfamily Member 2, Potassium Voltage-gated Channel Subfamily D Member 2, RK5, Shal1, Voltage-gated Potassium Channel Subunit Kv4.2, Voltage-sensitive Potassi

Cat no: K9018-02C


Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Kv4.2, a voltage-gated K+ (Kv) channel subunit, has been suggested to be the key component of the subthreshold A-type K+ currents (I(SA)s) recorded from the specific subcellular compartments of certain CNS neurons (1). A-type channels, encoded by the pore-forming alpha-subunits of the Kv4.x family, are particularly important in regulating membrane excitability in the CNS and the heart. Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus (2). Deletion of the Kv4.2 gene and a loss of Kv4.2 protein resulted in a specific and near-complete elimination of A-type K+ currents from the apical dendrites of CA1 pyramidal neurons. The absence of dendritic Kv4.2-encoded A-type K+ currents led to an increase of bAP amplitude and an increase of concurrent Ca2+ influx (3). Applications: Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:30 Western Blot: 1:1000 Immunohistochemistry: 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: K9018-02C
Reactivities: Human
Hosts: Rabbit
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Tsaur ML, et al. Chin J Physiol 44(3):133-14, 2001 2. Adams JP, et al. J Neurochem. 75(6):2277-87, 2000 3. Chen X, et al. J Neurosci 26(47):12143-51, 2006
Additional info: Recognizes human Kv4.2.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave