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Isocyclosporin A

Cat no: I8856-01

Supplier: United States Biological
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Isocyclosporin A is a rearranged degradation product formed by acid treatment oc cyclosporine A under in aqueous and non- aqueous conditions. This rearrangement has been used as the basis of a HPLC fluorescence for quantifying cyclosporin A. The pharmacology of isocyclosporin A has received little attention. Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: I8856-01
Size: 1mg
Form: Supplied as a white powder
Purity: ~98% (HPLC)
References: 1. Cyclosporin A, a peptide metabolite from Trichoderma polysporum, with remarkable immunosuppressive activity. Ruegger A. et al. Helv. Chim. Acta 1976, 59, 1075. 2. Hydrolysis of cyclosporin A: Identification of 1,11 seco-cyclosporin A and 4,5 seco-isocyclosporin A by FAB-MS/MS. Magni F. et al. Peptides 1995, 16, 1335. 3. Kinetics of acid-catalyzed degradation of cyclosporin A and its analogs in aqueous solution. Oliyai R. et al. Int. J. Pept. Protein Res. 1994, 43, 239. 4. Kinetics and mechanism of isomerization of cyclosporin A. Oliyai R. & Stella V. J. Pharm. Res. 1992, 9, 617. 5. Synthesis of a fluorescent derivative of cyclosporin A for high-performance liquid chromatography analysis. Fois R. A. & Ashley J. J. J. Pharm. Sci. 1991, 80, 363.

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