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Interleukin 6 Receptor (CD126, IL-6R) (PE)

Cat no: I8428-39M1

Supplier: United States Biological
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Interleukin 6 (IL-6) is a multifunctional cytokine that exerts its activities by binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80kD ligand binding subunit (IL-6 R/CD126) and a 130kD nonligand-binding signal-transducing subunit (gp130/CD130).1-4 Unlike gp130 that is expressed ubiquitously, the cellular distribution of IL-6 R is predominantly limited to hepatocytes and leukocyte subpopulations such as monocytes, neutrophils, T and B cells. Soluble IL-6 R has been found in various body fluids.5 Soluble IL-6 R binds IL-6 with an affinity similar to that of the membrane-bound IL-6 R. More importantly, the soluble IL-6 R/IL-6 complex is capable of interacting with the membrane-bound gp130 to activate cells that lack an integral membrane IL-6 R. It has been documented that elevated soluble IL-6 R is associated with numerous diseases including arthritic lesions, multiple myeloma and Crohn
Catalogue number: I8428-39M1
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with PE.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Yamasaki, K. et al., 1988, Science 241:825. 2. Sugita, T. et al., 1990, J. Exp. Med. 171:2001. 3. Hibi, M. et al., 1990, Cell 63:1149. 4. Saito, M. et al., 1992, J. Immunol. 148:4066. 5.Novick, D. et al., 1989, J. Exp. Med. 170:1409. 6. Jones, S.A. et al., 2001, FASEB J. 15:43. 7. Jones, S.A. and S. Rose-John, 2002, Biochim. Biophys. Acta 1592:251.
Additional info: Recognizes mouse IL-6R.

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