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Interleukin 4 (IL-4, B Cell Stimulatory Factor 1, BSF1, Binetrakin, HCGF, Hodgkin's Cell Growth Factor, IA Inducing Factor, Lymphocyte Stimulatory Factor 1, Macrophage Fusion Factor, Mast Cell Growth Factor 2, MCGF2, MFF, MGC79402, Pitrakinra, T Cell Grow

Cat no: I8426-11B


Supplier: United States Biological
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Interleukin-4 (IL-4) is a principal regulatory cytokine during an immune response and a crucial determinant for allergy and asthma. IL-4 binds with high affinity and specificity to the ectodomain of the IL-4 receptor alpha chain (IL4-BP). IL-4 The is a left-handed four-helix bundle with a short stretch of beta sheet. The structure bears close resemblance to other cytokines such as granulocyte-macrophage colony stimulating factor (GM-CSF). Regions have been identified which are not only important to maintain structure, but could also play a role in receptor binding (2). IL-4 antagonists Y124D and Y124G are presented and shown to be medically important. The site around Y124 is a particularly important epitope responsible for the ability of IL-4 to cause a signal in the target cells (3). Applications: Suitable for use in Immunocytochemistry and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: I8426-11B
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Hage T, et al. Cell 97(2):271-81, 1999 2. Wlodawer, A, et al. FEBS Lett 309(1):59-64, 1992 3. Muller T, et al. J Mol Biol 237(4):423-36, 1994
Additional info: Recognizes human IL-4.

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