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Interleukin 22 (IL-22, IL-10 Related T cell-derived Inducible Factor, IL-TIF) (PE)

Cat no: I8443-18F2

Supplier: United States Biological
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Interleukin 22 (IL-22), also called IL-10 related T cell-derived inducible factor or IL-TIF, is a secreted cytokine that contributes to the inflammatory response in vivo. IL-22 is expressed in T cells and mast cells in response to IL-9 or lipopolysaccharide. IL-22 monomers bind to a class II cytokine receptor that is a heterodimer of CRF2-9 (IL-22 Ra1) and CRF2-4 (IL-10 Rb). Mouse IL-22 is a 179 amino acid (aa) protein with a 33aa signal peptide, three N-glycosylation sites, and two intramolecular disulfide bonds. The mature protein shows 78% and 90% aa identity with human and rat IL-22, respectively. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: Neat; 10ul labels 5x10e5 cells. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C. Stable for 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Catalogue number: I8443-18F2
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, pH 7.4, 0.5% BSA, 0.1% sodium azide. Labeled with Phycoerythrin (PE).
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Dumoutier, L., et al., J. Immunol. 164: 1814 (2000). 2. Xie, M-H., et al., J. Biol. Chem. 275: 31,335 (2000). 3. Dumoutier, L., et al., PNAS 97: 10,144 (2000). 4. Kotenko, S.V., et al., J. Biol. Chem. 276: 2725 (2001).
Additional info: Recognizes mouse IL-22. Species Sequence Homology: human; 78% and rat; 90%

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