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Interleukin 17E (IL-17E, IL25, IL-25, Precursor, interleukin 25, Interleukin-25) (PE)

Cat no: I8443-60B

Supplier: United States Biological
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The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Mouse IL-17E cDNA encodes a 169 amino acid (aa) precursor protein with a putative 16 aa signal peptide. Mouse IL-17E shares from 24% to 32% sequence identity with the other mouse IL-17 family members. IL-17E expression was detected at very low levels by PCR in various peripheral tissues including brain, kidney, lung, prostate, testis, adrenal gland, spinal cord, and trachea. IL-17E binds and activates the IL-17 B Receptor (IL-17B R; alternatively known as IL-17 Rh1, IL-17E R, and EVI27) (3, 4) which is expressed in the kidney and liver, and at lower levels in the brain, testis and other endocrine tissues. The expression of IL-17B R is up-regulated under inflammatory conditions. Ligation of IL-17E to IL-17B R induces activation of nuclear factor kappa-B and stimulates the production of the proinflamatory cytokine IL-8. IL-17 has also been found to promote the expression of the prototypical Th2 genes. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: Neat. Use 10ul to label 5x10e5 cells. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C. Stable for 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Catalogue number: I8443-60B
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
References: 1. Aggarwal, S. and A.L. Gurney, 2002, J. Leukoc. Biol. 71:1 - 8.2. Moseley, T.A. et al., 2003, Cytokine & Growth Factor Rev. 14:155 - 174.3. Lee, J., et al., 2001, J. Biol. Chem. 276:1660 - 1664.4. Hurst, S.D. et al., 2002, J. Immunol. 169:443 - 453.5. Pan, G. et al., 2001, J. Immunol. 167:6569 - 6567.
Additional info: Recognizes mouse IL-17E.

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