Home  >  Products  >  Interleukin 17D (IL-17D) (PE)

Interleukin 17D (IL-17D) (PE)

Cat no: I8443-75G2

Supplier: United States Biological
0 reviews | Write a Review Pencil
The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus.1, 2, 6 With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers.3 IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions.1, 2, 6 Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members, have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL-17 RE, have also been reported.1-6 Mouse IL-17D is synthesized as a 205 aa precursor that contains a putative 24 amino acid (aa) signal peptide and a 181 aa mature segment. In the mature region, mouse IL-17D is 88% aa identical to human IL-17D. There is less that 30% aa identity between mouse IL-17D and other members of the mouse IL-17 family. IL-17D is expressed in skeletal muscle, adipose tissue, fetal liver, and heart, plus resting CD4+ T cells and CD19+ B cells.1 IL-17D binding to a mouse IL-17 R/Fc construct in a functional ELISA has neen shown. IL-17D is known to induce the production of IL-8, IL-6 and GM-CSF.5. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: Use 10ul to label 5x10e5 cells. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity.
Catalogue number: I8443-75G2
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with PE.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Aggarwal, S. and A.L. Gurney, (2002) J. Leukoc. Biol. 71:1-8. 2. Moseley, T.A. et al., (2003) Cytokine & Growth Factor Rev. 14:155-174. 3. Hymowitz, S.G. et al., (2001) EMBO J. 20:5332-5341. 4. Haudenschild, D. et al., (2002) J. Biol. Chem. 277:4309-4316. 5. Starnes, T. et al., (2002) J. Immunol. 169:642. 6. Kolls, J.K. and A. Linden, (2004) Immunity 21:467.
Additional info: Recognizes mouse IL-27.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave