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Interleukin 17D (IL-17D) (APC)

Cat no: I8443-75G1

Supplier: United States Biological
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The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members, have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL-17 RE, have also been reported. Mouse IL-17D is synthesized as a 205 amino acid (aa) precursor that contains a putative aa signal peptide and a 181 aa mature segment. The mature region contains two potential N-linked glycosylation sites and eight cysteines, four of which are involved in the formation of a modified cysteine-knot motif. The molecule is reported to exist as a 53kD disulfide-linked homodimer. Given that its predicted homodimeric molecular weight is 40kD, the molecule is presumably glycosylated. In the mature region, mouse IL-17D is 88% aa identical to human IL-17D. There is less that 30% aa identity between mouse IL-17D and other members of the mouse IL-17 family. IL-17D is expressed in skeletal muscle, adipose tissue, fetal liver, and heart, plus resting CD4+ T cells and CD19+ B cells. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow cytometry: Use 10ul to label 5x10e5 cells. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4 degrees C. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.
Catalogue number: I8443-75G1
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS containing 0.1% sodium azide. Labeled with APC.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Aggarwal, S. and A.L. Gurney, 2002, J. Leukoc. Biol. 71:1 - 8. 2. Moseley, T.A. et al., 2003 Cytokine & Growth Factor Rev. 14:155 - 174. 3. Hymowitz, S.G. et al., 2001, EMBO J. 20:5332 - 5341. 4. Haudenschild, D. et al., 2002, J. Biol. Chem. 277:4309 - 4316. 5. Starnes, T. et al., 2002, J. Immunol. 169:642. 6. Kolls, J.K. and A. Linden, 2004, Immunity 21:467.
Additional info: Recognizes mouse IL-17D.

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