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Interleukin 17B (IL-17B) (APC)

Cat no: I8439-20D

Supplier: United States Biological
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The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17, IL-17B through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus (1,2). With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers (3). IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions (1,2). Two receptors (IL-17 R, and IL-17B R), which are activated by IL-17 family members have been identified. In addition, at least three additional orphan type I transmembrane receptors with homology to IL-17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL-17 RE, have also been reported (1-4). The functions of IL-17 RC, D, and E are not known. Human IL-17B cDNA encodes a 180aa protein with a putative 20aa signal peptide (5,6). Human and mouse IL-17B share 88% amino acid sequence identity. Among IL-17 family members, IL-17B is most closely related to IL-17D, sharing 27% aa sequence homology. IL-17B is expressed highly in spinal cord, and at lower levels in brain, kidney, lung, small intestine, prostate, testes, pancreas, adrenal gland and trachea (5-7). Expression of IL-17B has also been detected in chondrocytes in articular cartilage (2). IL-17B binds the IL-17B receptor, but not IL-17 R and exhibits bioactivities distinct from those of IL-17 (5,6). Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C in the dark before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. for 12 months. Light sensitive.
Catalogue number: I8439-20D
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
References: 1. Aggarwal, S. and Gurney, A.L., J. Leukoc. Biol. 71: 1-8 (2002). 2. Moseley, T.A., et al., Cytokine & Growth Factor Rev. 14: 155-174 (2003). 3. Hymowitz, S.G., et al., EMBO J. 20: 5332-5341 (2001). 4. Haudenschild, D., et al., J. Biol. Chem. 277: 4309-4316 (2002). 5. Shi, Y., et al., J. Biol. Chem. 275: 19,167-19,176 (2000). 6. Li, H., et al., Proc. Natl. Acad. Sci. USA 97: 773-778 (2000). 7. Moore, E.E., et al., Neuromuscul. Disord. 12: 141-150 (2002).
Additional info: Recognizes human IL-17b.

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