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Interleukin 17 Receptor (IL-17R, CTLA8, IL-17RA, Interleukin-17 Receptor A) (PE)

Cat no: I8439-03B

Supplier: United States Biological
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Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine. IL-17 binds to IL-17 receptor (IL-17 R), which shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested. The hIL-17 R gene was localized to chromosome 22. Human IL-17 R is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of hIL-17 R is 69% identical to the mIL-17 R. The signaling events of IL-17 include activation of NF-kB and JNK, and require TNF receptor-associated factor 6 (TRAF6). Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: neat. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Catalogue number: I8439-03B
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with PE.
P type: Mab
Isotype: IgG1
Purity: Purified immunoglobulin
References: 1. Yao, Z. et al., 1997, Cytokine 9:794 2. Schwander, R. et al., 2000, J. Exp. Med. 191:1233.
Additional info: Recognizes human IL-17.

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