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Interleukin 17 Receptor (IL-17R, CTLA8, IL-17RA, Interleukin-17 Receptor A) (APC)

Cat no: I8439-03

Supplier: United States Biological
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Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine. IL-17 binds to IL-17 receptor (IL-17 R), which shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested. The hIL-17 R gene was localized to chromosome 22. Human IL-17 R is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of hIL-17 R is 69% identical to the mIL-17 R. The signaling events of IL-17 include activation of NF-kB and JNK, and require TNF receptor-associated factor 6 (TRAF6). Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.
Catalogue number: I8439-03
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100Tests
Form: Supplied as a liquid in PBS, BSA. Conjugated to APC.
P type: Mab
Isotype: IgG1
Purity: Purified immunoglobulin
References: 1. Yao, Z. et al., 1997, Cytokine 9:794. 2. Schwander, R. et al., 2000, J. Exp. Med. 191:1233.
Additional info: Recognizes human IL-17.

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