Home  >  Products  >  IkB alpha (I-kappa-B alpha, I(kappa)B(alpha), IkappaBalpha, IkB-alpha, IkBa, Major Histocompatibility Complex Enhancer Binding Protein MAD3, MAD-3, NF-kappa-B Inhibitor alpha, NFKBIa, NFKBI, Nuclear Factor of kappa Light Chain Gene Enhancer in B cells, Nu
IkB alpha (I-kappa-B alpha, I(kappa)B(alpha), IkappaBalpha, IkB-alpha, IkBa, Major Histocompatibility Complex Enhancer Binding Protein MAD3, MAD-3, NF-kappa-B Inhibitor alpha, NFKBIa, NFKBI, Nuclear Factor of kappa Light Chain Gene Enhancer in B cells, Nu

IkB alpha (I-kappa-B alpha, I(kappa)B(alpha), IkappaBalpha, IkB-alpha, IkBa, Major Histocompatibility Complex Enhancer Binding Protein MAD3, MAD-3, NF-kappa-B Inhibitor alpha, NFKBIa, NFKBI, Nuclear Factor of kappa Light Chain Gene Enhancer in B cells, Nu

Cat no: I2500-03J

Supplier: United States Biological
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NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB (1). Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-6). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified (1). One of the first gene induced following NF-kB activation is IkBa. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: Daudi, Jurkat, or NIH 3T3 Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: I2500-03J
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: As reported
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
Additional info: A 40kD band is observed. The antibody reacts with human and mouse IkBa. Species Crossreactivity: Human, Mouse.

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