Home  >  Products  >  ICAD (Inhibitor of CAD, ICAD-L, ICAD-S, DNA Fragmentation Factor Subunit alpha, Dffa, DFF35, DNA Fragmentation Factor 45 kD Subunit, Dff45, DFF-45)

ICAD (Inhibitor of CAD, ICAD-L, ICAD-S, DNA Fragmentation Factor Subunit alpha, Dffa, DFF35, DNA Fragmentation Factor 45 kD Subunit, Dff45, DFF-45)

Cat no: I0505-05D


Supplier: United States Biological
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Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as many other types of diseases. Recently, a human DNA fragmentation factor (DFF45) was identified. DFF is composed of two subunts: DFF40 and DFF45. Cleavage of DFF45, which is mediated by caspase-3, leads to DFF40's activation as a nuclease. Activation of DFF40 can lead to DNA fragmentation, a hallmark of apoptosis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: I0505-05D
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes mouse DFF45 at ~28kD and ~45kD. Species Crossreactivity: rat.

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